Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.36 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20045450 | 0.88 | FPR2 (0.43) | FPR2PIK3CAUSP30PIK3R1ESR2 | |
| SCHEMBL29222684 | 0.80 | NR1H2 (0.36) | PIK3CAUSP30NR1H2HDAC1SMARCA2 | |
| SCHEMBL31184875 | 0.78 | FPR2 (0.44) | FPR2USP30SCN9A | |
| SCHEMBL31749583 | 0.78 | FPR2 (0.48) | FPR2USP30NR1H2HDAC1ESR2 | |
| SCHEMBL20046198 | 0.76 | FPR2 (0.42) | FPR2PIK3CAUSP30PIK3R1NR1H2 | |
| SCHEMBL20045536 | 0.74 | FPR2 (0.41) | FPR2PIK3CAUSP30NR1H2SCN9A | |
| SCHEMBL121297 | 0.72 | NAMPT (0.50) | FPR2USP30SCN9A | |
| SCHEMBL20046204 | 0.71 | FPR2 (0.48) | FPR2PIK3CAUSP30ESR2 | |
| SCHEMBL20133028 | 0.70 | USP30 (0.43) | FPR2USP30NR1H2HDAC1SCN9A | |
| SCHEMBL24558149 | 0.70 | USP30 (0.35) | FPR2PIK3CAUSP30PIK3R1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068017-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2018-04-12 | — | — | WO | disclosed |