SCHEMBL200459

SCHEMBL200459

CCCCCCCCCCCCCCCCSC

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.53
THRB P10828 2/20 0.53
CA2 P00918 1/20 0.46
TRPA1 O75762 3/20 0.42
HSD17B10 Q99714 2/20 0.42
CES2 O00748 1/20 0.42
CTSL P07711 1/20 0.42
CTSB P07858 1/20 0.42
GMNN O75496 1/20 0.42
TP53 P04637 1/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 1/20 0.42
CYP2C9 P11712 1/20 0.42
BLM P54132 1/20 0.42
DNM1 Q05193 6/20 0.41
ALDH1A1 P00352 2/20 0.40
LMNA P02545 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL200481 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL199323 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL12749540 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL200935 1.00
SCHEMBL22214867 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL387242 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL202027 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL198940 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL198830 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10
SCHEMBL200493 1.00 TSHR (0.53) TSHRTHRBCA2TRPA1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240216290-A1 LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF RECODE THERAPEUTICS, INC. 2024-07-04 US disclosed
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2024-07-04 US disclosed
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2024-06-27 US disclosed
US-20230338411-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS RECODE THERAPEUTICS, INC. 2023-10-26 US disclosed
US-20230293429-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS RECODE THERAPEUTICS, INC. 2023-09-21 US disclosed
US-9770442-B2 Self-assembling amphiphilic polymers as anti-cancer agents ALLEXCEL INC. (US) 2017-09-26 US disclosed
US-9671392-B2 Multisensor array for detection of analytes or mixtures thereof in gas or liquid phase DANMARKS TEKNISKE UNIVERSITET (DK) 2017-06-06 US disclosed
EP-1142983-B1 Lubricant additive IDEMITSU KOSAN CO (JP) 2016-02-24 EP disclosed
EP-1736530-B1 LUBRICATING OIL COMPOSITION FOR CONTINUOUSLY VARIABLE TRANSMISSION IDEMITSU KOSAN CO (JP) 2016-02-03 EP disclosed
EP-2512521-B1 DENDRITIC HIGH-MOLECULAR-WEIGHT POLYMER DRUG CARRIERS AND THEIR CONJUGATES WITH DRUGS ESPECIALLY FOR TREATMENT OF SOLID TUMOURS USTAV MAKROMOLEKULARNI CHEMIE (CZ) 2014-02-26 EP disclosed
US-20020055441-A1 Lubricant additive IDEMITSU KOSAN CO., LTD. (JP) 2002-05-09 US disclosed
US-6352962-B1 ADDITIVE FOR TRACTION DRIVE FLUID OBTAINED BY HEATING AT LEAST ONE ESTER SELECTED FROM ACIDIC PHOSPHATE ESTER AND PHOSPHITE ESTER AND SUCCINIMIDE DISPERSANT CONTAINING BORON AT TEMPERATURE OF 120 TO 150 DEGREES C. FOR 5 HOURS OR MORE IDEMITSU KOSAN CO., LTD. (JP) 2002-03-05 US disclosed
US-6303546-B1 CONTAINING PHOSPHATE ESTER, BORON-CONTAINING IMIDE BASE DISPERSANT AND BORON-FREE IMIDE BASE DISPERSANT IDEMITSU KOSAN CO., LTD. (JP) 2001-10-16 US disclosed
EP-1142983-A1 Lubricant additive IDEMITSU KOSAN COMPANY LIMITED (JP) 2001-10-10 EP disclosed
WO-2001070750-A1 METHOD FOR ADDING SI- OR GE-BONDED HYDROGEN TO AN ALIPHATIC CARBON-CARBON MULTIPLE BOND WACKER-CHEMIE GMBH (DE) 2001-09-27 WO disclosed
EP-1057884-A1 Traction drive fluid IDEMITSU KOSAN COMPANY LIMITED (JP) 2000-12-06 EP disclosed
EP-1057882-A1 Lubricating oil composition for cellulose base wet friction material IDEMITSU KOSAN CO., LTD. (JP) 2000-12-06 EP disclosed
US-5273410-A Compressor exhibiting an iron sulfide wear surface KABUSHIKI KAISHA TOSHIBA (JP) 1993-12-28 US disclosed
EP-0438922-A1 Refrigerant compressor for HFC 134a KABUSHIKI KAISHA TOSHIBA (JP) 1991-07-31 EP disclosed
US-4246125-A ALIPHATIC HYDROCARBYL SULFINYL OR SULFONYL METHANE EDWIN COOPER, INC. (US) 1981-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240207178-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 TSHR 2262/4885THRB 2609/4885CA2 1829/4885
US-20240216290-A1 LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF LIPA, NPC1L1, NPC1 TSHR 3323/4885THRB 4690/4885CA2 4324/4885
US-20240216515-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS PNLIP, LIPA, PHOSPHO1 TSHR 2016/4885THRB 1435/4885CA2 1905/4885
US-20230293429-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 TSHR 2262/4885THRB 2609/4885CA2 1829/4885
US-20230338411-A1 COMPOSITIONS AND METHODS FOR TARGETED DELIVERY TO CELLS CHMP4B, LIPA, NPC1L1 TSHR 2262/4885THRB 2609/4885CA2 1829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.