Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 3/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20045982 | 0.86 | FPR2 (0.42) | FPR2USP30NR1H2NAMPTSCN9A | |
| SCHEMBL20045983 | 0.80 | PIK3CA (0.35) | USP30NR1H2NAMPTSCN9AESR2 | |
| SCHEMBL30167498 | 0.75 | NAMPT (0.35) | FPR2USP30NAMPTBACE1 | |
| SCHEMBL30167475 | 0.75 | FPR2 (0.47) | FPR2USP30NR1H2NAMPTSCN9A | |
| SCHEMBL31749583 | 0.74 | FPR2 (0.48) | FPR2USP30NR1H2NAMPTESR2 | |
| SCHEMBL20045530 | 0.72 | USP30 (0.47) | FPR2USP30NR1H2NAMPTKRAS | |
| SCHEMBL24187307 | 0.71 | SIGMAR1 (0.49) | FPR2USP30NR1H2ESR2RORC | |
| SCHEMBL7144319 | 0.70 | USP30 (0.49) | FPR2USP30NR1H2NAMPTESR2 | |
| SCHEMBL5359160 | 0.70 | USP30 (0.49) | FPR2USP30NR1H2NAMPTESR2 | |
| SCHEMBL7144317 | 0.70 | USP30 (0.49) | FPR2USP30NR1H2NAMPTESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018068017-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF RAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2018-04-12 | — | — | WO | disclosed |