Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20045986 | 0.82 | USP30 (0.48) | AAK1USP30KRAS | |
| SCHEMBL28328842 | 0.81 | BCHE (0.41) | MEN1KMT2AHTTCARM1PRMT6 | |
| SCHEMBL28566889 | 0.77 | USP30 (0.55) | USP30HTTKRAS | |
| SCHEMBL28566888 | 0.77 | USP30 (0.55) | USP30HTTKRAS | |
| SCHEMBL28777851 | 0.74 | MEN1 (0.40) | MEN1KMT2ACARM1PRMT6 | |
| SCHEMBL21874640 | 0.71 | GRM2 (0.40) | AAK1USP30KMT2AHTTGRM2 | |
| SCHEMBL21874641 | 0.71 | GRM2 (0.40) | AAK1USP30KMT2AHTTGRM2 | |
| SCHEMBL27945898 | 0.70 | CARM1 (0.57) | KMT2ACARM1PRMT6 | |
| Tert-Butyl Formate SCHEMBL28327683 | 0.70 | SSTR4 (0.34) | AAK1MEN1KMT2AHTTLMNA | |
| SCHEMBL27765294 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110312711-A | Heterocyclic compound and its application method as RAS inhibitor | 亚瑞克西斯制药公司 | 2019-10-08 | — | — | CN | disclosed |