Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 6/20 | 0.77 |
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | CDC25B | P30305 | 3/20 | 0.55 |
| ▸ | NSD2 | O96028 | 5/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.52 |
| ▸ | G6PD | P11413 | 1/20 | 0.52 |
| ▸ | CCR6 | P51684 | 1/20 | 0.52 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.52 |
| ▸ | APAF1 | O14727 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | CASP3 | P42574 | 3/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046780 | 0.91 | CDC25A (0.70) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL17249976 | 0.87 | CDC25A (1.00) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL20046743 | 0.78 | CDC25A (0.55) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL15630326 | 0.77 | CDC25A (0.81) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL16745430 | 0.76 | IDO1 (0.75) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL29881216 | 0.76 | IDO1 (0.75) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL20046820 | 0.76 | CDC25A (0.51) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL20046782 | 0.75 | MAPT (0.65) | CDC25AMAPTLMNAHTTNSD2 | |
| SCHEMBL12283411 | 0.72 | CDC25A (0.71) | CDC25AMAPTLMNAHTTCDC25B | |
| SCHEMBL15906861 | 0.71 | MAPT (0.75) | CDC25AMAPTLMNAHTTCDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE | 2020-09-10 | — | — | US | disclosed |
| WO-2018067842-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2018-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | MCL1, NPM1, ABL1 | CDC25A 938/4885MAPT 4723/4885LMNA 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.