Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.65 |
| ▸ | APAF1 | O14727 | 2/20 | 0.65 |
| ▸ | TDP2 | O95551 | 2/20 | 0.65 |
| ▸ | CASP6 | P55212 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CDC25A | P30304 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046780 | 0.83 | CDC25A (0.70) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL20046743 | 0.80 | CDC25A (0.55) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL20046774 | 0.75 | CDC25A (0.77) | MAPTMAPK1GAAMEN1KMT2A | |
| 2-Methoxyanthraquinone SCHEMBL222927 | 0.75 | PTPN1 (0.60) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL23111380 | 0.74 | PTPRC (0.59) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL4645032 | 0.74 | PTPN1 (0.58) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL20046820 | 0.72 | CDC25A (0.51) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL16745457 | 0.72 | ALKBH3 (0.52) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL2997273 | 0.70 | PTPN1 (0.54) | MAPTMAPK1GAAMEN1KMT2A | |
| SCHEMBL17439396 | 0.70 | MAPT (0.55) | MAPTMAPK1GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE | 2020-09-10 | — | — | US | disclosed |
| WO-2018067842-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2018-04-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | MCL1, NPM1, ABL1 | MAPT 4723/4885MAPK1 1131/4885GAA 4338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.