Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.75 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.75 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.75 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | CDC25B | P30305 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | TDP2 | O95551 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | S100A4 | P26447 | 2/20 | 0.52 |
| ▸ | APAF1 | O14727 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29881216 | 1.00 | IDO1 (0.75) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| SCHEMBL16745426 | 0.87 | APAF1 (0.58) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| SCHEMBL20046946 | 0.87 | IDO1 (0.58) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| SCHEMBL9627597 | 0.86 | IDO1 (0.62) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| Dichlon SCHEMBL29360991 | 0.86 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| Dichlon SCHEMBL45723 | 0.86 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| Dichlon SCHEMBL9751236 | 0.86 | IDO1 (1.00) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| Dichlon SCHEMBL10794085 | 0.83 | IDO1 (0.94) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| Dichlon SCHEMBL5077878 | 0.83 | IDO1 (0.94) | IDO1DNMT1DNMT3LDNMT3AKMT2A | |
| SCHEMBL22413400 | 0.82 | PTPRC (0.67) | IDO1DNMT1DNMT3LDNMT3AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE | 2020-09-10 | — | — | US | disclosed |
| WO-2018067842-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2018-04-12 | — | — | WO | disclosed |
| US-9481662-B2 | Seriniquinones, melanoma-specific anticancer agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-01 | — | — | US | disclosed |
| US-9481662-B2 | Seriniquinones, melanoma-specific anticancer agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150148314-A1 | SERINIQUINONES, MELANOMA-SPECIFIC ANTICANCER AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-28 | — | — | US | disclosed |
| US-20150148314-A1 | SERINIQUINONES, MELANOMA-SPECIFIC ANTICANCER AGENTS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148314-A1 | SERINIQUINONES, MELANOMA-SPECIFIC ANTICANCER AGENTS | SDHA, KLK3, BRDT | IDO1 616/4885DNMT1 1521/4885DNMT3L 643/4885 |
| US-20200283417-A1 | AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA | MCL1, NPM1, ABL1 | IDO1 494/4885DNMT1 1810/4885DNMT3L 4444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.