⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22873448 | 0.88 | — | — | |
| SCHEMBL23483083 | 0.85 | HCRTR2 (0.31) | — | |
| SCHEMBL22692181 | 0.84 | CDC25B (0.31) | — | |
| SCHEMBL25059067 | 0.83 | SLC6A2 (0.32) | — | |
| SCHEMBL20046476 | 0.82 | NCF1 (0.33) | — | |
| SCHEMBL23594210 | 0.81 | HRH3 (0.35) | — | |
| SCHEMBL20046569 | 0.81 | HRH3 (0.35) | — | |
| SCHEMBL23133520 | 0.79 | — | — | |
| SCHEMBL22692330 | 0.78 | — | — | |
| SCHEMBL22692185 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331681-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS, INC. | 2023-10-19 | — | — | US | disclosed |
| US-10844021-B2 | Compounds and methods for the targeted degradation of androgen receptor | ARVINAS OPERATIONS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
| US-20180099940-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS, INC. | 2018-04-12 | — | — | US | disclosed |