⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046814 | 0.88 | — | — | |
| SCHEMBL22692181 | 0.81 | CDC25B (0.31) | — | |
| SCHEMBL25059067 | 0.81 | SLC6A2 (0.32) | — | |
| SCHEMBL20046476 | 0.79 | NCF1 (0.33) | — | |
| SCHEMBL23594210 | 0.78 | HRH3 (0.35) | — | |
| SCHEMBL20046569 | 0.78 | HRH3 (0.35) | — | |
| SCHEMBL23133520 | 0.76 | — | — | |
| SCHEMBL22692330 | 0.76 | — | — | |
| SCHEMBL22692185 | 0.75 | — | — | |
| SCHEMBL23483083 | 0.73 | HCRTR2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236051-B2 | Compounds and methods for the targeted degradation of androgen receptor | ARVINAS OPERATIONS, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210009528-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. | 2021-01-14 | — | — | US | disclosed |