Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ESRRB | O95718 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ESRRA | P11474 | 1/20 | 0.54 |
| ▸ | ESRRG | P62508 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27446673 | 0.95 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL20046925 | 0.90 | GPR119 (0.54) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL22873406 | 0.89 | GPR119 (0.47) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL20046630 | 0.87 | GPR119 (0.49) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL20046247 | 0.87 | GPR119 (0.47) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL23460548 | 0.86 | GPR119 (0.51) | KMT2AMEN1GPR119MAPTLMNA | |
| SCHEMBL20046840 | 0.86 | GPR119 (0.50) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL20046619 | 0.86 | GPR119 (0.49) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL25170650 | 0.85 | MEN1 (0.56) | KMT2ASMN1; SMN2MEN1CYP2C19HTT | |
| SCHEMBL1742370 | 0.84 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2MEN1CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180099940-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS, INC. | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180099940-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | AR, ADRM1, CRBN | KMT2A 1478/4885SMN1; SMN2 3936/4885MEN1 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.