Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12223728 | 0.80 | ALDH1A1 (0.63) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL9502860 | 0.78 | ALDH1A1 (0.62) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL23382244 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL15931713 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL12197486 | 0.77 | ALDH1A1 (0.60) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL25333351 | 0.76 | ALDH1A1 (0.56) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL16093587 | 0.76 | ALDH1A1 (0.67) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL29224422 | 0.76 | ALDH1A1 (0.59) | ALDH1A1LMNAGLAMAPK1SMN1; SMN2 | |
| SCHEMBL26409868 | 0.75 | CYP2C19 (0.42) | ALDH1A1LMNAGLS | |
| SCHEMBL21992355 | 0.75 | MAPT (0.39) | ALDH1A1TP53KDM4EMAPTGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067615-A1 | COMPOUNDS, DEVICES, AND USES THEREOF | SIGILON THERAPEUTICS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |