Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12223728 | 0.89 | ALDH1A1 (0.63) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL15931713 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL23382244 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL16093587 | 0.85 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL29224422 | 0.85 | ALDH1A1 (0.59) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL2027803 | 0.84 | MGAM (0.46) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL25333351 | 0.82 | ALDH1A1 (0.56) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL3677898 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL9325575 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HPGDGLA | |
| SCHEMBL29224532 | 0.80 | ALDH1A1 (0.54) | ALDH1A1LMNASMN1; SMN2HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0321187-B1 | 6-(SUBSTITUTED METHYLENE)PENEMS | BEECHAM GROUP PLC (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4931434-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-06-05 | — | — | US | disclosed |
| US-4923856-A | Penem compounds | BEECHAM GROUP P.L.C. (GB) | 1990-05-08 | — | — | US | disclosed |
| EP-0321186-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |
| EP-0321187-A1 | 6-(Substituted methylene)penems | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |