Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MPO | P05164 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694694 | 0.88 | ALDH1A1 (0.64) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL9591675 | 0.86 | KDM4E (0.63) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL18736598 | 0.86 | ALDH1A1 (0.61) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL19689020 | 0.86 | TP53 (0.68) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL112540 | 0.85 | ALDH1A1 (0.67) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL16642162 | 0.85 | ALDH1A1 (0.67) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL16896997 | 0.84 | ALDH1A1 (0.59) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL2992964 | 0.84 | ALDH1A1 (1.00) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| Isoniazid SCHEMBL28090501 | 0.83 | KDM4E (0.95) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 | |
| SCHEMBL6614688 | 0.83 | KDM4E (0.70) | ALDH1A1KDM4EMPOCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964613-B2 | (S)-3-amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine; inhibits phosphorylation of myosin regulatory light chain; for spinal canal stenosis, spinal cord injury, rheumatoid arthritis, multiple sclerosis; Rho kinase inhibitors | ASAHI KASEI PHARMA CORPORATION (JP) | 2011-06-21 | — | — | US | disclosed |
| EP-2130828-A1 | SULFONAMIDE DERIVATIVE | Asahi Kasei Pharma Corporation (JP) | 2009-12-09 | — | — | EP | disclosed |
| US-20090048223-A1 | Sulfonamide compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048223-A1 | Sulfonamide compound | ALK, AKT1, ARAF | ALDH1A1 3529/4885KDM4E 1897/4885MPO 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.