Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 11/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 10/20 | 0.60 |
| ▸ | AR | P10275 | 9/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23131108 | 1.00 | PGR (0.60) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL20048255 | 0.88 | PGR (0.62) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL21470226 | 0.88 | PGR (0.62) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL23131152 | 0.88 | PGR (0.62) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL23381659 | 0.82 | PGR (0.62) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL18306390 | 0.78 | PGR (0.60) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL19032618 | 0.78 | PGR (0.60) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL1591672 | 0.78 | PGR (0.60) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL19042720 | 0.78 | PGR (0.60) | PGRNR3C1ARCYP3A4SERPINA6 | |
| SCHEMBL20048358 | 0.78 | NR3C1 (0.76) | PGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523315-B1 | INHIBITOR OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS INC (US) | 2021-03-24 | — | — | EP | disclosed |
| WO-2018068021-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |