Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.67 |
| ▸ | PGR | P06401 | 12/20 | 0.67 |
| ▸ | AR | P10275 | 9/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | SHBG | P04278 | 3/20 | 0.55 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | SNCA | P37840 | 2/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.55 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.55 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19042636 | 0.91 | NR3C1 (0.65) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL19042770 | 0.86 | NR3C1 (0.68) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL20048426 | 0.85 | NR3C1 (0.58) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL20048428 | 0.85 | NR3C1 (0.53) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL23653484 | 0.84 | NR3C1 (0.79) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL23131149 | 0.84 | NR3C1 (0.56) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL23131104 | 0.81 | NR3C1 (0.66) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL20048253 | 0.81 | NR3C1 (0.66) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL23131180 | 0.81 | NR3C1 (0.51) | NR3C1PGRARLMNAHSD17B10 | |
| SCHEMBL20048337 | 0.80 | NR3C1 (1.00) | NR3C1PGRARCYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523315-B1 | INHIBITOR OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS INC (US) | 2021-03-24 | — | — | EP | disclosed |
| WO-2018068021-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | ORIC PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |