Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.79 |
| ▸ | PGR | P06401 | 14/20 | 0.79 |
| ▸ | AR | P10275 | 10/20 | 0.79 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22903977 | 0.88 | NR3C1 (0.73) | NR3C1PGRARCYP2C8SHBG | |
| SCHEMBL20048337 | 0.88 | NR3C1 (1.00) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL20048338 | 0.87 | NR3C1 (0.85) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL19042676 | 0.86 | NR3C1 (0.80) | NR3C1PGRARCYP2C8ALDH1A1 | |
| SCHEMBL20048342 | 0.86 | NR3C1 (0.85) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL20048433 | 0.84 | NR3C1 (0.67) | NR3C1PGRARCYP2C8SHBG | |
| SCHEMBL22861575 | 0.81 | NR3C1 (1.00) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL19042671 | 0.81 | NR3C1 (1.00) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL19042678 | 0.81 | NR3C1 (0.70) | NR3C1PGRARCYP2C8SHBG | |
| SCHEMBL19042707 | 0.80 | NR3C1 (0.83) | NR3C1PGRARCYP2C8SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3851444-A1 | INHIBITORS OF GLUCOCORTICOID RECEPTOR | Oric Pharmaceuticals, Inc. (US) | 2021-07-21 | — | — | EP | disclosed |