Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | KLK6 | Q92876 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KLK8 | O60259 | 1/20 | 0.38 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8291790 | 0.82 | JAK2 (0.47) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL3394416 | 0.82 | PTGS1 (0.44) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL1165573 | 0.78 | KDM4E (0.68) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL31487317 | 0.78 | KDM4E (0.68) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL8296306 | 0.76 | PRSS1 (0.55) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL11331437 | 0.76 | KDM4E (0.49) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL8291738 | 0.76 | KDM4E (0.69) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL6222629 | 0.75 | GAA (0.63) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL5190391 | 0.74 | JAK2 (0.55) | KDM4ELMNAGAAALDH1A1MAPT | |
| SCHEMBL1191675 | 0.74 | KDM4E (0.51) | KDM4ELMNAGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065607-A1 | CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN RELATED PEPTIDASE 6 (KLK6) | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2018-04-12 | — | — | WO | disclosed |