Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | CASP7 | P55210 | 2/20 | 0.43 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1191675 | 0.89 | KDM4E (0.51) | PTGS1PTGS2KDM4ELMNAALDH1A1 | |
| SCHEMBL8291790 | 0.84 | JAK2 (0.47) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL31381374 | 0.83 | KDM4E (0.63) | PTGS1PTGS2KDM4EALDH1A1MAPT | |
| SCHEMBL20048439 | 0.82 | KDM4E (0.43) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL1165573 | 0.80 | KDM4E (0.68) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL31487317 | 0.80 | KDM4E (0.68) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL13229806 | 0.78 | LMNA (0.47) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL11331437 | 0.78 | KDM4E (0.49) | KDM4ELMNAALDH1A1MAPTGAA | |
| SCHEMBL9938004 | 0.78 | GAA (0.60) | PTGS1PTGS2LMNAALDH1A1MAPT | |
| SCHEMBL8291738 | 0.78 | KDM4E (0.69) | KDM4ELMNAALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240408064-A1 | RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF | GENETOLEAD INC. (CA) | 2024-12-12 | — | — | US | disclosed |
| US-20110060026-A1 | Indoles Active on CRTH2 Receptor | PULMAGEN THERAPEUTICS (ASTHMA) LIMITED (GB) | 2011-03-10 | — | — | US | disclosed |
| EP-2245010-A1 | INDOLES ACTIVE ON CRTH2 RECEPTOR | Pulmagen Therapeutics (Asthma) Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009090399-A1 | INDOLES ACTIVE ON CRTH2 RECEPTOR | ARGENTA DISCOVERY LIMITED (GB) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110060026-A1 | Indoles Active on CRTH2 Receptor | ARRB1, GPR3, HRH3 | PTGS1 1454/4885PTGS2 1372/4885KDM4E 4402/4885 |
| US-20240408064-A1 | RAS INHIBITORS, COMPOSITIONS AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | PTGS1 2106/4885PTGS2 2960/4885KDM4E 4019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.