SCHEMBL20048495

SCHEMBL20048495

CSc1ccccc1NC(=O)[C@H]1C(=O)N(C)C[C@@H]1c1cccc(C)c1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.43
NPSR1 Q6W5P4 2/20 0.40
LMNA P02545 2/20 0.40
USP2 O75604 1/20 0.40
MAPT P10636 5/20 0.38
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
RAB9A P51151 2/20 0.38
HPGD P15428 1/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
OPRK1 P41145 1/20 0.37
LPAR2 Q9HBW0 1/20 0.37
KMT2A Q03164 4/20 0.37
MEN1 O00255 3/20 0.37
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20048569 0.88 HSD17B10 (0.46) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL26215922 0.87 MEN1 (0.44) NPSR1LMNAUSP2MAPTALDH1A1
SCHEMBL20048493 0.87 MEN1 (0.44) NPSR1LMNAUSP2MAPTALDH1A1
SCHEMBL20043858 0.87 HSD17B10 (0.43) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL20043911 0.87 HSD17B10 (0.45) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL20043952 0.87 HSD17B10 (0.41) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL20048479 0.86 ALDH1A1 (0.46) HSD17B10LMNAMAPTALDH1A1RAB9A
SCHEMBL20044133 0.85 HSD17B10 (0.43) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL20044410 0.85 HSD17B10 (0.41) HSD17B10NPSR1LMNAMAPTALDH1A1
SCHEMBL20044122 0.85 HSD17B10 (0.41) HSD17B10NPSR1LMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2024-01-25 US disclosed
US-11787765-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2023-10-17 US disclosed
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2022-04-28 US disclosed
US-11180453-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2021-11-23 US disclosed
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2020-11-05 US disclosed
US-10654804-B2 Substituted cyclic amides and their use as herbicides FMC CORPORATION (US) 2020-05-19 US disclosed
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES FMC CORPORATION 2018-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11787765-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885
US-20180099935-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885
US-10654804-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885
US-20240025853-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HSD17B10 1933/4885NPSR1 429/4885LMNA 3944/4885
US-20220127229-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885
US-20200347017-A1 SUBSTITUTED CYCLIC AMIDES AND THEIR USE AS HERBICIDES NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885
US-11180453-B2 Substituted cyclic amides and their use as herbicides NIT2, ARG1, CNPY2 HSD17B10 1966/4885NPSR1 420/4885LMNA 3917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.