Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8413987 | 0.81 | CHRM1 (0.41) | TSHR | |
| SCHEMBL8414423 | 0.78 | RNPEP (0.39) | — | |
| SCHEMBL11723613 | 0.76 | GRM2 (0.34) | DPP8DPP7DPP4KIF11 | |
| SCHEMBL21984836 | 0.76 | THRB (0.30) | — | |
| SCHEMBL7761207 | 0.76 | — | — | |
| SCHEMBL7347545 | 0.75 | TSHR (0.42) | FFAR3TSHR | |
| SCHEMBL1706440 | 0.75 | MAPT (0.31) | FFAR3 | |
| SCHEMBL7347552 | 0.75 | TSHR (0.42) | FFAR3TSHR | |
| SCHEMBL8200989 | 0.75 | CTRB1 (0.38) | — | |
| SCHEMBL765722 | 0.75 | EPHX1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |