Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | POLQ | O75417 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15287109 | 0.85 | P2RX7 (0.44) | P2RX7TAS2R14KDM4EHDAC1HDAC8 | |
| SCHEMBL30474543 | 0.84 | POLQ (0.55) | POLQKDM4EHDAC1HDAC8ALDH1A1 | |
| SCHEMBL871601 | 0.84 | POLQ (0.55) | POLQKDM4EHDAC1HDAC8ALDH1A1 | |
| SCHEMBL31645683 | 0.83 | P2RX7 (0.47) | P2RX7POLQKDM4EPTGS2 | |
| SCHEMBL15524632 | 0.79 | NOTUM (0.43) | TAS2R14KDM4EHDAC1HDAC8NOTUM | |
| SCHEMBL20049209 | 0.78 | P2RX7 (0.48) | P2RX7POLQKDM4EALDH1A1HTT | |
| SCHEMBL31614159 | 0.78 | CA12 (0.44) | KDM4EALDH1A1LMNAGAA | |
| SCHEMBL4179574 | 0.78 | CA12 (0.44) | KDM4EALDH1A1LMNAGAA | |
| SCHEMBL20045091 | 0.78 | KDM4E (0.43) | KDM4ETDP1PTGS2L3MBTL1SMN1; SMN2 | |
| SCHEMBL17398610 | 0.76 | SMN1; SMN2 (0.47) | KDM4EALDH1A1HTTPTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11207283-B2 | Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | NORTHWESTERN UNIVERSITY (US) | 2021-12-28 | — | — | US | disclosed |
| US-20200281880-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | NORTHWESTERN UNIVERSITY (US) | 2020-09-10 | — | — | US | disclosed |
| US-10632088-B2 | Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | NORTHWESTERN UNIVERSITY (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180098952-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | NORTHWESTERN UNIVERSITY (US) | 2018-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180098952-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | OAT, OTC, ABAT | P2RX7 3699/4885TAS2R14 3869/4885POLQ 1808/4885 |
| US-11207283-B2 | Inactivators of toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | OAT, OTC, ABAT | P2RX7 3699/4885TAS2R14 3869/4885POLQ 1808/4885 |
| US-20200281880-A1 | INACTIVATORS OF TOXOPLASMA GONDII ORNITHINE AMINOTRANSFERASE FOR TREATING TOXOPLASMOSIS AND MALARIA | OAT, OTC, ABAT | P2RX7 3699/4885TAS2R14 3869/4885POLQ 1808/4885 |
| US-10632088-B2 | Inactivators of Toxoplasma gondii ornithine aminotransferase for treating toxoplasmosis and malaria | OAT, OTC, ABAT | P2RX7 3699/4885TAS2R14 3869/4885POLQ 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.