Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 8/20 | 0.68 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.37 |
| ▸ | SELE | P16581 | 1/20 | 0.37 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433969 | 0.88 | STING1 (0.72) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL29636411 | 0.87 | STING1 (0.67) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL20022282 | 0.87 | STING1 (0.67) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL29636407 | 0.87 | STING1 (0.67) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL20022281 | 0.87 | STING1 (0.67) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL26931552 | 0.85 | STING1 (0.61) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL30682886 | 0.85 | STING1 (0.61) | STING1CCNCCDK8HDAC3HDAC4 | |
| SCHEMBL26931877 | 0.85 | STING1 (0.75) | STING1CCNCCDK8 | |
| SCHEMBL20022180 | 0.84 | STING1 (0.82) | STING1 | |
| SCHEMBL20049611 | 0.83 | STING1 (0.81) | STING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067423-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-12 | — | — | WO | disclosed |