Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 10/20 | 0.72 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29636407 | 0.90 | STING1 (0.67) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20022281 | 0.90 | STING1 (0.67) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20049321 | 0.88 | STING1 (0.68) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29636411 | 0.87 | STING1 (0.67) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20022282 | 0.87 | STING1 (0.67) | STING1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27522380 | 0.86 | STING1 (0.54) | STING1TBXAS1HDAC3HDAC4HDAC1 | |
| SCHEMBL26949623 | 0.85 | STING1 (0.54) | STING1TBXAS1HDAC3HDAC4HDAC1 | |
| SCHEMBL30682860 | 0.85 | STING1 (0.54) | STING1TBXAS1HDAC3HDAC4HDAC1 | |
| SCHEMBL26931877 | 0.85 | STING1 (0.75) | STING1CCNCCDK8 | |
| SCHEMBL25274256 | 0.84 | STING1 (0.53) | STING1TBXAS1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361253-A1 | STING AGONIST COMPOUNDS | SUTRO BIOPHARMA INC (US) | 2025-11-27 | — | — | US | disclosed |
| EP-4536672-A1 | STING AGONIST COMPOUNDS | Sutro Biopharma, Inc. (US) | 2025-04-16 | — | — | EP | disclosed |
| CN-119654330-A | STING agonist compounds | 苏特罗生物制药公司 | 2025-03-18 | — | — | CN | disclosed |
| WO-2023239675-A1 | STING AGONIST COMPOUNDS | SUTRO BIOPHARMA, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239675-A1 | STING AGONIST COMPOUNDS | SUTRO BIOPHARMA, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| CN-111971277-B | Benzothiophenes and related compounds as STING agonists | 默沙东有限责任公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-110036001-B | Benzo [ b ] thiophene compounds as STING agonists | 默沙东公司 | 2022-03-22 | — | — | CN | disclosed |
| WO-2021113679-A1 | DIMERIC COMPOUNDS AS STING AGONISTS | MERSANA THERAPEUTICS, INC. (US) | 2021-06-10 | — | — | WO | disclosed |
| CN-111971277-A | Benzothiophenes and related compounds as STING agonists | 默沙东公司 | 2020-11-20 | — | — | CN | disclosed |
| US-10793557-B2 | Sting agonist compounds | MERCK SHARP & DOHME CORP. (US) | 2020-10-06 | — | — | US | disclosed |
| US-10414747-B2 | Benzo[b]thiophene compounds as sting agonists | MERCK SHARP & DOHME CORP. (US) | 2019-09-17 | — | — | US | disclosed |
| EP-3523287-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | Merck Sharp & Dohme Corp. (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018067423-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-12 | — | — | WO | disclosed |
| WO-2018067423-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-12 | — | — | WO | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
| EP-0482717-B1 | Use of a benzo[b]thiophene-2-carboximidamide derivative against heart failure | AKZO NOBEL NV (NL) | 1994-06-08 | — | — | EP | disclosed |
| US-5276052-A | For treatment of heart failure | AKZO N.V. (NL) | 1994-01-04 | — | — | US | disclosed |
| EP-0482717-A1 | Use of a benzo[b]thiophene-2-carboximidamide derivative against heart failure | Akzo Nobel N.V. (NL) | 1992-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | STING1 1/4885TBXAS1 26/4885HDAC3 4365/4885 |
| US-10793557-B2 | Sting agonist compounds | STING1, CGAS, IRF3 | STING1 1/4885TBXAS1 32/4885HDAC3 4824/4885 |
| US-10414747-B2 | Benzo[b]thiophene compounds as sting agonists | STING1, IRF3, CGAS | STING1 1/4885TBXAS1 26/4885HDAC3 4365/4885 |
| US-20250361253-A1 | STING AGONIST COMPOUNDS | STING1, CGAS, MAVS | STING1 1/4885TBXAS1 124/4885HDAC3 4660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.