Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049390 | 0.81 | CHRNB2 (0.39) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL21098334 | 0.78 | CHRNB2 (0.37) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL21098342 | 0.76 | CHRNB2 (0.35) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL21097746 | 0.76 | CHRNB2 (0.35) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL22255018 | 0.74 | ALDH1A1 (0.39) | MAPTNPC1SMN1; SMN2ALOX15ATM | |
| SCHEMBL22672609 | 0.74 | NPC1 (0.47) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL22672659 | 0.69 | NPC1 (0.44) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL22672583 | 0.69 | NPC1 (0.44) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 | |
| SCHEMBL16615785 | 0.64 | SMN1; SMN2 (0.58) | MAPTNPC1SMN1; SMN2ALOX15ATM | |
| SCHEMBL18587304 | 0.62 | CHRNB2 (0.54) | CHRNB2CHRNA4MAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |