Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047725 | 0.95 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL20049487 | 0.90 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL20049126 | 0.87 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL20043335 | 0.87 | NR1H4 (0.65) | NR1H4 | |
| SCHEMBL20047724 | 0.85 | NR1H4 (0.66) | NR1H4 | |
| SCHEMBL10084823 | 0.85 | NR1H4 (1.00) | NR1H4 | |
| SCHEMBL20043352 | 0.85 | NR1H4 (0.78) | NR1H4 | |
| SCHEMBL20043396 | 0.84 | NR1H4 (0.62) | NR1H4 | |
| SCHEMBL22789910 | 0.83 | NR1H4 (0.76) | NR1H4 | |
| SCHEMBL20047736 | 0.83 | NR1H4 (0.61) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067704-A1 | ISOXAZOLE ANALOGS AS FXR AGONISTS AND METHODS OF USE THEREOF | ENANTA PHARMACEUTICALS, INC. (US) | 2018-04-12 | — | — | WO | disclosed |