Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ADCY5 | O95622 | 5/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049565 | 0.87 | PDPK1 (0.39) | PDPK1ACACBGPR119PRMT5WDR77 | |
| SCHEMBL20049592 | 0.80 | PRMT5 (0.44) | PDPK1ACACBGPR119PRMT5WDR77 | |
| SCHEMBL19714858 | 0.79 | PDPK1 (0.40) | PDPK1ACACBGPR119PRMT5WDR77 | |
| SCHEMBL25047421 | 0.79 | JAK1 (0.38) | ACACBGPR119PRMT5WDR77UBA6 | |
| SCHEMBL18572228 | 0.72 | PDPK1 (0.40) | PDPK1GPR119JAK3 | |
| SCHEMBL25949266 | 0.72 | PDPK1 (0.37) | PDPK1ACACBGPR119PRMT5WDR77 | |
| SCHEMBL22002163 | 0.72 | PDPK1 (0.37) | PDPK1ACACBGPR119PRMT5WDR77 | |
| SCHEMBL18571923 | 0.72 | PDPK1 (0.40) | PDPK1GPR119JAK3 | |
| SCHEMBL22002066 | 0.70 | PDPK1 (0.36) | PDPK1GPR119PRMT5WDR77JAK3 | |
| SCHEMBL23892341 | 0.70 | PDPK1 (0.36) | PDPK1GPR119PRMT5WDR77JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018065365-A1 | NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |