Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002066 | 1.00 | PDPK1 (0.36) | PDPK1GPR119JAK3ADKPRMT5 | |
| SCHEMBL25949326 | 0.92 | GPR119 (0.33) | GPR119JAK3ADK | |
| SCHEMBL25949266 | 0.92 | PDPK1 (0.37) | PDPK1GPR119JAK3ADKPRMT5 | |
| SCHEMBL22002163 | 0.92 | PDPK1 (0.37) | PDPK1GPR119JAK3ADKPRMT5 | |
| SCHEMBL18571923 | 0.84 | PDPK1 (0.40) | PDPK1GPR119JAK3 | |
| SCHEMBL18572228 | 0.84 | PDPK1 (0.40) | PDPK1GPR119JAK3 | |
| SCHEMBL23892580 | 0.83 | GPR119 (0.33) | GPR119JAK3ADKPRMT5WDR77 | |
| SCHEMBL25948966 | 0.80 | ABL1 (0.37) | PDPK1GPR119JAK3 | |
| SCHEMBL23892335 | 0.80 | ABL1 (0.37) | PDPK1GPR119JAK3 | |
| SCHEMBL22002064 | 0.77 | PRMT5 (0.35) | PDPK1PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |