Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049805 | 0.81 | GRIN2B (0.40) | GRIN2BGRIN1 | |
| SCHEMBL6984523 | 0.75 | L3MBTL1 (0.42) | — | |
| SCHEMBL20049979 | 0.74 | GRIN1 (0.43) | GRIN2BGRIN1GSK3B | |
| SCHEMBL20049950 | 0.74 | GSK3A (0.52) | GSK3BHDAC1HDAC2 | |
| SCHEMBL25586500 | 0.73 | HSD17B10 (0.47) | GRIN2BGRIN1 | |
| SCHEMBL25544940 | 0.72 | PIK3C3 (0.44) | GRIN2BGRIN1SLC6A7 | |
| SCHEMBL21613634 | 0.71 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL25547252 | 0.69 | GRIN2B (0.41) | GRIN2BGRIN1GSK3B | |
| SCHEMBL7091354 | 0.69 | L3MBTL1 (0.40) | — | |
| SCHEMBL19736372 | 0.69 | AGBL2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |