Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25588074 | 0.88 | CHRNA7 (0.38) | CYP1A2CYP2C19CHRNA7RAB9AMAP4K4 | |
| SCHEMBL20049775 | 0.85 | NPC1 (0.42) | CHRNA7RAB9ASCN10ANPC1GRIN1 | |
| SCHEMBL20049803 | 0.85 | CHRNA7 (0.47) | CHRNA7RAB9ANPC1SMN1; SMN2GRIN1 | |
| SCHEMBL20049886 | 0.85 | PSMB5 (0.42) | RAB9AMAP4K4NPC1HTT | |
| SCHEMBL20049984 | 0.85 | ESR2 (0.47) | RAB9AMAP4K4NPC1SMN1; SMN2GRIN1 | |
| SCHEMBL25584752 | 0.84 | GRIN2B (0.43) | CHRNA7GRIN1GRIN2B | |
| SCHEMBL20049991 | 0.83 | PDGFRB (0.40) | CHRNA7NPC1GRIN1GRIN2B | |
| SCHEMBL20050098 | 0.83 | CHRNA7 (0.42) | CHRNA7RAB9ANPC1SMN1; SMN2EGLN1 | |
| SCHEMBL25588581 | 0.83 | EPHB4 (0.42) | RAB9ANPC1SMN1; SMN2EPHB4TEK | |
| SCHEMBL25588429 | 0.80 | GRIN1 (0.35) | MAP4K4NPC1GRIN1GRIN2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |