Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | VEGFA | P15692 | 3/20 | 0.40 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.39 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049830 | 0.86 | EGLN1 (0.41) | EGLN1MAP4K4GRIN1GRIN2B | |
| SCHEMBL20049970 | 0.85 | GRM5 (0.43) | ESR2RAB9ANPC1SMN1; SMN2EGLN1 | |
| SCHEMBL20049908 | 0.85 | CYP1A2 (0.40) | RAB9ANPC1SMN1; SMN2EGLN1EGLN3 | |
| SCHEMBL20049886 | 0.84 | PSMB5 (0.42) | RAB9ANPC1MAPTMAP4K4KDR | |
| SCHEMBL20049803 | 0.82 | CHRNA7 (0.47) | RAB9ANPC1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL25584752 | 0.81 | GRIN2B (0.43) | GRIN1GRIN2B | |
| SCHEMBL20049967 | 0.81 | ALDH1A1 (0.52) | GRIN1GRIN2B | |
| SCHEMBL20049842 | 0.81 | NEK1 (0.43) | EGLN1MAP4K4GRM5GRIN1GRIN2B | |
| SCHEMBL20050025 | 0.80 | CDK8 (0.39) | MAP4K4GRIN1GRIN2B | |
| SCHEMBL20049905 | 0.80 | MKNK1 (0.44) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |