Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 8/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25588340 | 0.81 | CYP1A2 (0.53) | CYP1A2CYP3A4CYP2D6LRRK2GRIN1 | |
| SCHEMBL20049815 | 0.80 | PSMB5 (0.47) | MAP4K4CYP1A2CYP3A4CYP2D6CYP2A6 | |
| SCHEMBL20049894 | 0.79 | MAP4K4 (0.45) | MAP4K4GRIN1GRIN2BFGFR3KDR | |
| SCHEMBL20050084 | 0.78 | MAP4K4 (0.48) | MAP4K4CYP3A4GRIN1GRIN2BFGFR3 | |
| SCHEMBL25586131 | 0.78 | CNR2 (0.44) | GRIN1GRIN2B | |
| SCHEMBL20049954 | 0.76 | PDGFRB (0.41) | MAP4K4CYP3A4LRRK2CYP2A6CYP2C19 | |
| SCHEMBL20050011 | 0.76 | USP2 (0.40) | MAP4K4CYP1A2CYP3A4CYP2D6CYP2A6 | |
| SCHEMBL25586483 | 0.74 | GRIN2B (0.42) | CYP1A2CYP3A4CYP2D6GRIN1GRIN2B | |
| SCHEMBL20049975 | 0.74 | GRIN1 (0.36) | MAP4K4CYP1A2CYP3A4CYP2D6CYP2A6 | |
| SCHEMBL25583779 | 0.74 | CHRNA7 (0.49) | GRIN2BPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |