Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049954 | 0.83 | PDGFRB (0.41) | CYP2A6MAP4K4PSMB5PDGFRBPDGFRA | |
| SCHEMBL20049894 | 0.82 | MAP4K4 (0.45) | GRIN1GRIN2BMAP4K4FGFR3KDR | |
| SCHEMBL20050011 | 0.79 | USP2 (0.40) | CYP2A6MAP4K4FGFR3KDRPDGFRB | |
| SCHEMBL20049815 | 0.79 | PSMB5 (0.47) | CYP2A6MAP4K4PSMB5FGFR3KDR | |
| SCHEMBL25588429 | 0.78 | GRIN1 (0.35) | GRIN1GRIN2BMAP4K4PSMB5FYN | |
| SCHEMBL13199572 | 0.77 | NOS3 (0.48) | CYP2A6NOS3NOS2CYP1A2CYP3A4 | |
| SCHEMBL25583779 | 0.77 | CHRNA7 (0.49) | GRIN2BPDGFRBPDGFRAFYN | |
| Hydrochloric Acid SCHEMBL28718520 | 0.75 | NOS3 (0.46) | CYP2A6NOS3NOS2CYP1A2CYP3A4 | |
| SCHEMBL25586426 | 0.75 | GRIN2B (0.45) | GRIN1GRIN2BMAP4K4KDRCYP1A2 | |
| SCHEMBL20049971 | 0.74 | MAP4K4 (0.40) | GRIN1GRIN2BCYP2A6MAP4K4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |