Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049886 | 0.85 | PSMB5 (0.42) | CLK4KDRNPC1HTTRAB9A | |
| SCHEMBL25588722 | 0.84 | GRM5 (0.46) | CYP1A2CYP3A4ALDH1A1TSHRCYP2C19 | |
| SCHEMBL20049904 | 0.83 | GRIN2B (0.42) | ALDH1A1ABL1GRIN2BGRIN1NPC1 | |
| SCHEMBL20049825 | 0.82 | GSK3B (0.42) | ALDH1A1CLK4GRIN2BGRIN1NPC1 | |
| SCHEMBL25588340 | 0.80 | CYP1A2 (0.53) | CNR1CYP1A2CYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL25588074 | 0.79 | CHRNA7 (0.38) | CYP1A2ALDH1A1CYP2C19L3MBTL1NPC1 | |
| SCHEMBL20049948 | 0.79 | ABL1 (0.43) | ALDH1A1ABL1L3MBTL1GRIN2BGRIN1 | |
| SCHEMBL20049830 | 0.78 | EGLN1 (0.41) | CNR1KITGRIN2BGRIN1 | |
| SCHEMBL20050100 | 0.78 | GRM5 (0.34) | CYP1A2CYP3A4ALDH1A1TSHRCYP2C19 | |
| SCHEMBL25588536 | 0.78 | ABL1 (0.43) | ALDH1A1ABL1KITNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |