Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | LCK | P06239 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049967 | 0.82 | ALDH1A1 (0.52) | GRIN1GRIN2BALDH1A1L3MBTL1SLC1A3 | |
| SCHEMBL20049992 | 0.79 | CNR1 (0.39) | ABL1GRIN1GRIN2BKDRMAPK14 | |
| SCHEMBL20049904 | 0.76 | GRIN2B (0.42) | ABL1GRIN1GRIN2BALDH1A1 | |
| SCHEMBL25588581 | 0.76 | EPHB4 (0.42) | TEKTRPV1 | |
| SCHEMBL20049825 | 0.73 | GSK3B (0.42) | GRIN1GRIN2BALDH1A1MAPK13MAPK12 | |
| SCHEMBL20050027 | 0.73 | GRIN2B (0.44) | GRIN1GRIN2B | |
| SCHEMBL20049775 | 0.73 | NPC1 (0.42) | ABL1GRIN1GRIN2BKDRTEK | |
| SCHEMBL20049886 | 0.73 | PSMB5 (0.42) | KDR | |
| SCHEMBL25588074 | 0.73 | CHRNA7 (0.38) | ALDH1A1L3MBTL1 | |
| SCHEMBL25584752 | 0.72 | GRIN2B (0.43) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |