Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 13/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.38 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049775 | 0.86 | NPC1 (0.42) | GRIN2BGRIN1ABL1NPC1ALDH1A1 | |
| SCHEMBL20049992 | 0.83 | CNR1 (0.39) | GRIN2BGRIN1ABL1NPC1ALDH1A1 | |
| SCHEMBL20050027 | 0.83 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL20050000 | 0.81 | ABL1 (0.39) | GRIN2BGRIN1ABL1NPC1ALDH1A1 | |
| SCHEMBL20049838 | 0.81 | NPC1 (0.38) | GRIN2BGRIN1ABL1NPC1ALDH1A1 | |
| SCHEMBL20049814 | 0.81 | GRIN2B (0.44) | GRIN2BGRIN1ABL1EIF2AK3EIF2S1 | |
| SCHEMBL20049970 | 0.81 | GRM5 (0.43) | GRIN2BGRIN1NPC1ALDH1A1RAB9A | |
| SCHEMBL20049825 | 0.80 | GSK3B (0.42) | GRIN2BGRIN1NPC1ALDH1A1 | |
| SCHEMBL25584752 | 0.79 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL20049991 | 0.78 | PDGFRB (0.40) | GRIN2BGRIN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067786-A1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-04-12 | — | — | WO | disclosed |