Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014512 | 0.88 | ALDH1A1 (0.49) | ALDH1A1NPC1LMNAEPHX2POLB | |
| SCHEMBL22435981 | 0.82 | KMT2A (0.45) | ALDH1A1NPC1EPHX2POLBKMT2A | |
| SCHEMBL22891887 | 0.79 | DPP4 (0.43) | ALDH1A1NPC1LMNAEPHX2POLB | |
| SCHEMBL18767354 | 0.79 | DPP4 (0.43) | ALDH1A1NPC1LMNAEPHX2POLB | |
| SCHEMBL10275024 | 0.77 | KMT2A (0.69) | ALDH1A1NPC1LMNAPOLBKMT2A | |
| SCHEMBL12384714 | 0.75 | CYP2D6 (0.43) | LMNAEPHX2KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20481757 | 0.75 | ALDH1A1 (0.48) | ALDH1A1NPC1LMNAEPHX2POLB | |
| SCHEMBL10122345 | 0.75 | LMNA (0.47) | ALDH1A1NPC1LMNAEPHX2POLB | |
| SCHEMBL14032638 | 0.74 | ALDH1A1 (0.49) | ALDH1A1NPC1LMNAPOLBKMT2A | |
| SCHEMBL2606067 | 0.74 | ALDH1A1 (0.52) | ALDH1A1NPC1LMNAPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018067422-A1 | NOVEL JAK1 SELECTIVE INHIBITORS AND USES THEREOF | LIANG CONGXIN (US) | 2018-04-12 | — | — | WO | disclosed |