Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004484 | 0.94 | KDM4E (0.38) | LMNAF2RL3RETKDM4EALDH1A1 | |
| SCHEMBL2002744 | 0.92 | F2RL3 (0.40) | LMNAMAPK1F2RL3KDM4EALDH1A1 | |
| SCHEMBL2004592 | 0.92 | ALOX5AP (0.41) | LMNAMAPK1HTTKDM4EALDH1A1 | |
| SCHEMBL2008151 | 0.92 | LMNA (0.39) | LMNAMAPK1F2RL3KDM4EALDH1A1 | |
| SCHEMBL2010466 | 0.91 | RET (0.38) | LMNAMAPK1RETKDM4EALDH1A1 | |
| SCHEMBL2006961 | 0.91 | LMNA (0.40) | LMNAMAPK1HTTF2RL3KDM4E | |
| SCHEMBL2008130 | 0.90 | ALOX5AP (0.39) | LMNAMAPK1HTTF2RL3RET | |
| SCHEMBL2003814 | 0.90 | F2RL3 (0.36) | LMNAF2RL3RETKDM4EALDH1A1 | |
| SCHEMBL2005825 | 0.89 | RET (0.38) | LMNAMAPK1RETKDM4EALDH1A1 | |
| SCHEMBL2004562 | 0.89 | RET (0.37) | LMNAMAPK1RETKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |