Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17082955 | 0.71 | LMNA (0.64) | KMT2ARAB9AMEN1CASP3SMN1; SMN2 | |
| SCHEMBL17082944 | 0.70 | LMNA (0.66) | KMT2ARAB9AMEN1CASP3SMN1; SMN2 | |
| SCHEMBL15127501 | 0.68 | MAPT (0.79) | KMT2ARAB9AMEN1HTTSMN1; SMN2 | |
| SCHEMBL11072116 | 0.67 | KMT2A (0.49) | KMT2ARAB9AMEN1NPC1HTT | |
| SCHEMBL11255607 | 0.66 | MAPT (0.56) | KMT2ARAB9AMEN1NPC1HTT | |
| SCHEMBL17082974 | 0.65 | LMNA (0.47) | KMT2ARAB9AMEN1CASP3ALDH1A1 | |
| SCHEMBL1949475 | 0.65 | HPGD (0.56) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 | |
| SCHEMBL8389436 | 0.65 | MAPT (0.45) | KMT2ARAB9AMEN1NPC1HTT | |
| SCHEMBL5573133 | 0.65 | ALDH1A1 (0.44) | KMT2AMEN1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18485397 | 0.65 | ALDH1A1 (0.50) | KMT2ARAB9AMEN1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944607-B2 | Thiohydantoin derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-17 | — | — | US | disclosed |