Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15298476 | 0.85 | GAA (0.49) | GAARECQLTSHRALDH1A1POLB | |
| SCHEMBL20053362 | 0.79 | SMN1; SMN2 (0.37) | GAAALDH1A1SMN1; SMN2ATMKDM4E | |
| SCHEMBL23100380 | 0.79 | CHRNB2 (0.42) | GAAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL20053361 | 0.77 | CHRNB2 (0.50) | GAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12384433 | 0.75 | GAA (0.56) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL12083952 | 0.75 | GAA (0.56) | GAATSHRALDH1A1POLBHTT | |
| SCHEMBL18307651 | 0.74 | GAA (0.48) | GAARECQLTSHRALDH1A1POLB | |
| SCHEMBL14243070 | 0.74 | CHRNB2 (0.51) | GAARECQLTSHRALDH1A1POLB | |
| SCHEMBL6509490 | 0.74 | GAA (0.48) | GAARECQLTSHRALDH1A1POLB | |
| SCHEMBL15424547 | 0.74 | GAA (0.48) | GAARECQLTSHRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10259818-B2 | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors | INCYTE CORPORATION (US) | 2019-04-16 | — | — | US | disclosed |
| US-20190002470-A1 | BICYCLIC AZAHETEROCYCLOBENZYLAMINES AS PI3K INHIBITORS | INCYTE CORPORATION | 2019-01-03 | — | — | US | disclosed |
| US-9944646-B2 | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2018-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190002470-A1 | BICYCLIC AZAHETEROCYCLOBENZYLAMINES AS PI3K INHIBITORS | PIK3CD, PIK3CA, PIK3CB | GAA 1435/4885RECQL 2919/4885TSHR 3477/4885 |
| US-10259818-B2 | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors | PIK3CD, PIK3CA, PIK3CB | GAA 1435/4885RECQL 2919/4885TSHR 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.