Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23100380 | 0.83 | CHRNB2 (0.42) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL24778454 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL20053361 | 0.82 | CHRNB2 (0.50) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL20615648 | 0.81 | KMT2A (0.52) | SMN1; SMN2ALDH1A1LMNAGAACHRNB2 | |
| SCHEMBL20901012 | 0.79 | KDM4E (0.37) | SMN1; SMN2ALDH1A1LMNAMAPTGAA | |
| SCHEMBL20053294 | 0.79 | GAA (0.46) | SMN1; SMN2ALDH1A1MAPTGAAATM | |
| SCHEMBL15298469 | 0.78 | ATM (0.38) | SMN1; SMN2ALDH1A1LMNAMAPTCHRNB2 | |
| SCHEMBL24159163 | 0.76 | ATM (0.36) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL20615644 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL19177013 | 0.73 | EPHX2 (0.41) | SMN1; SMN2ALDH1A1LMNAMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944646-B2 | Bicyclic azaheterocyclobenzylamines as PI3K inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2018-04-17 | — | — | US | disclosed |