Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 10/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18849078 | 0.93 | HCRTR1 (0.40) | HCRTR1HCRTR2MTORPIK3CAGPR119 | |
| SCHEMBL20053537 | 0.92 | DYRK1A (0.41) | HCRTR1HCRTR2MTORPIK3CAGPR119 | |
| SCHEMBL15538347 | 0.91 | PIK3CA (0.45) | HCRTR1HCRTR2MTORPIK3CAATM | |
| SCHEMBL21535010 | 0.91 | HCRTR1 (0.42) | HCRTR1HCRTR2MTORPIK3CAGPR119 | |
| SCHEMBL15538344 | 0.91 | PIK3CA (0.45) | HCRTR1HCRTR2MTORPIK3CAATM | |
| SCHEMBL15539839 | 0.91 | PIK3CA (0.45) | HCRTR1HCRTR2MTORPIK3CAATM | |
| SCHEMBL21043258 | 0.90 | MTOR (0.43) | HCRTR1HCRTR2MTORPIK3CAGPR119 | |
| SCHEMBL18848898 | 0.90 | MTOR (0.43) | HCRTR1HCRTR2MTORPIK3CAGPR119 | |
| SCHEMBL15538191 | 0.89 | RARA (0.42) | GPR119KCNH2LIPEATMWDR5 | |
| SCHEMBL20053648 | 0.87 | CYP2D6 (0.44) | GPR119HRH3LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |