SCHEMBL20053594

SCHEMBL20053594

CC(C)(F)CN1CCC(COc2ccc(-c3ccc(C(=O)N4CCCC4)cc3F)nc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 7/20 0.46
CYP4F2 P78329 8/20 0.41
CYP4A11 Q02928 8/20 0.41
ADRB2 P07550 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
RBP4 P02753 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15539563 0.92 ALOX5AP (0.42) GPR119CYP4F2CYP4A11
SCHEMBL15539561 0.92 ALOX5AP (0.42) GPR119CYP4F2CYP4A11
SCHEMBL18849010 0.92 GPR119 (0.43) GPR119CYP4F2CYP4A11ADRB2HRH3
SCHEMBL15538840 0.91 GPR119 (0.42) GPR119CYP4F2CYP4A11
SCHEMBL15540003 0.90 GPR119 (0.43) GPR119CYP4F2CYP4A11HRH3
SCHEMBL15540005 0.90 GPR119 (0.43) GPR119CYP4F2CYP4A11HRH3
SCHEMBL15539786 0.90 GPR119 (0.43) GPR119CYP4F2CYP4A11
SCHEMBL15540430 0.88 GPR119 (0.44) GPR119CYP4F2CYP4A11
SCHEMBL20053536 0.88 GPR119 (0.40) GPR119ADRB2HRH3
SCHEMBL15539479 0.87 POLB (0.46) GPR119CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9944600-B2 Piperidine derivatives for GPR119 agonist CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2018-04-17 US disclosed