Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.39 |
| ▸ | FEN1 | P39748 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LIPE | Q05469 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537622 | 0.91 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PDK2 | |
| SCHEMBL15538128 | 0.91 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PDK2 | |
| SCHEMBL15537623 | 0.91 | ALOX5AP (0.46) | GPR119ALOX5APFEN1PDK2 | |
| SCHEMBL15538136 | 0.90 | ALOX5AP (0.44) | GPR119ALOX5APFEN1PDK2PARP1 | |
| SCHEMBL15538137 | 0.90 | ALOX5AP (0.44) | GPR119ALOX5APFEN1PDK2PARP1 | |
| SCHEMBL15538976 | 0.89 | GPR119 (0.42) | GPR119ALOX5APFEN1KCNH2 | |
| SCHEMBL20053594 | 0.88 | GPR119 (0.46) | GPR119HRH3ADRB2 | |
| SCHEMBL15538429 | 0.87 | GPR119 (0.41) | GPR119ALOX5APFEN1LIPE | |
| SCHEMBL20053577 | 0.87 | GPR119 (0.45) | GPR119HPGDCYP2D6KCNH2HRH3 | |
| SCHEMBL15538342 | 0.87 | PDK2 (0.41) | GPR119ALOX5APFEN1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858986-B1 | PIPERIDINE DERIVATIVES AS GPR119 AGONISTS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-9944600-B2 | Piperidine derivatives for GPR119 agonist | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2018-04-17 | — | — | US | disclosed |