Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.48 |
| ▸ | KDM6B | O15054 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | KDM4A | O75164 | 2/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582070 | 0.82 | KDM4C (0.50) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5740286 | 0.81 | KDM4C (0.49) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL20462852 | 0.79 | KDM4C (0.46) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL3932429 | 0.79 | KDM4C (0.48) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL30716135 | 0.77 | KDM4C (0.44) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL26850357 | 0.77 | KDM4C (0.44) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL30716134 | 0.77 | KDM4C (0.44) | KDM4CKDM6BKMT2AMEN1ALDH1A1 | |
| SCHEMBL17403394 | 0.75 | TSHR (0.57) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL1904536 | 0.75 | TSHR (0.57) | KMT2AMEN1ALDH1A1TDP1KDM4E | |
| SCHEMBL21961149 | 0.75 | TSHR (0.57) | KMT2AMEN1ALDH1A1TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944644-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-04-17 | — | — | US | disclosed |