Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 10/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20055168 | 0.88 | MPL (0.47) | KDM4ELMNAHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL10278422 | 0.86 | CYP1A2 (0.50) | KDM4ELMNAHSD17B10ALDH1A1AAK1 | |
| SCHEMBL2706815 | 0.86 | KDM4E (0.49) | KDM4ELMNAHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL10141265 | 0.81 | ALDH1A1 (0.60) | KDM4ELMNAHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL9980120 | 0.81 | SCN10A (0.48) | KDM4ELMNAHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL20055596 | 0.78 | GAA (0.43) | KDM4EAAK1HDAC3HDAC1HDAC8 | |
| SCHEMBL20055347 | 0.76 | CYP1A2 (0.48) | KDM4ELMNAHSD17B10ALDH1A1AAK1 | |
| SCHEMBL2705606 | 0.73 | KDM4E (0.65) | KDM4ELMNAHSD17B10ALDH1A1ALOX15 | |
| SCHEMBL13070866 | 0.73 | SCN10A (0.43) | KDM4EAAK1HTTKMT2A | |
| SCHEMBL9980127 | 0.73 | ALDH1A1 (0.48) | KDM4EHSD17B10ALDH1A1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |