Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 8/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PLD2 | O14939 | 2/20 | 0.40 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19112773 | 0.85 | CACNA1I (0.53) | CACNA1IKCNH2CACNA1HCYP2D6TAS1R3 | |
| SCHEMBL20056118 | 0.84 | CCR2 (0.57) | CACNA1IKCNH2HDAC6CCR2EPHX2 | |
| SCHEMBL4274691 | 0.83 | CACNA1I (0.46) | CACNA1IKCNH2CACNA1HCYP2D6TAS1R3 | |
| SCHEMBL19112774 | 0.82 | CACNA1I (0.47) | CACNA1IKCNH2CACNA1HCYP2D6TAS1R3 | |
| SCHEMBL19112915 | 0.81 | EPHX2 (0.52) | CACNA1IKCNH2HTR4CCR2EPHX2 | |
| SCHEMBL19112806 | 0.79 | CACNA1I (0.50) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL19113215 | 0.78 | CACNA1I (0.52) | CACNA1IKCNH2CACNA1HCYP2D6HTR4 | |
| SCHEMBL20056105 | 0.77 | CACNA1I (0.49) | CACNA1IKCNH2CACNA1HCYP2D6TAS1R3 | |
| SCHEMBL20056421 | 0.76 | CACNA1I (0.48) | CACNA1IKCNH2CACNA1HCYP2D6KDM1A | |
| SCHEMBL4274753 | 0.76 | CACNA1I (0.46) | CACNA1IKCNH2CACNA1HCYP2D6KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |