Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20056105 | 0.87 | CACNA1I (0.49) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL4275097 | 0.85 | CACNA1I (0.47) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL4274753 | 0.84 | CACNA1I (0.46) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL19113586 | 0.83 | CCR2 (0.58) | CACNA1IKCNH2HDAC6HDAC4HDAC3 | |
| SCHEMBL19112773 | 0.80 | CACNA1I (0.53) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL19112774 | 0.77 | CACNA1I (0.47) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL19112506 | 0.77 | ACHE (0.41) | CACNA1IKCNH2HDAC6KDM1ABCHE | |
| SCHEMBL20056037 | 0.76 | CACNA1I (0.48) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL4274691 | 0.76 | CACNA1I (0.46) | CACNA1IKCNH2CACNA1HCYP2D6HDAC6 | |
| SCHEMBL19113212 | 0.71 | KCNH2 (0.59) | CACNA1IKCNH2CACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |