Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.57 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19226529 | 0.85 | NAMPT (0.59) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL4280597 | 0.85 | ALDH1A1 (0.52) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL19112716 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL4275124 | 0.84 | ALDH1A1 (0.51) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL19113313 | 0.83 | CARM1 (0.56) | CACNA1IKCNH2CACNA1HCYP2D6CARM1 | |
| SCHEMBL15317662 | 0.82 | MAPK14 (0.57) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL19113003 | 0.81 | KCNH2 (0.55) | CACNA1IKCNH2CACNA1HCYP2D6CARM1 | |
| SCHEMBL17886674 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL17886696 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAGAAMAPTMAPK1 | |
| SCHEMBL19112707 | 0.80 | CACNA1I (0.74) | CACNA1IKCNH2CACNA1HCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |