Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 12/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569815 | 0.95 | CACNA1I (0.60) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL13569701 | 0.88 | CACNA1I (0.55) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL4280554 | 0.87 | CACNA1I (0.64) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL16471372 | 0.82 | CACNA1I (0.67) | CACNA1IKCNH2CACNA1GCACNA1HCCR2 | |
| SCHEMBL4284041 | 0.79 | CACNA1I (0.58) | CACNA1IKCNH2CACNA1GCACNA1HCCR2 | |
| SCHEMBL13569695 | 0.79 | KCNH2 (0.62) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL14769919 | 0.79 | KCNH2 (0.66) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL4274625 | 0.79 | KCNH2 (0.60) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL19113176 | 0.78 | KCNH2 (0.58) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 | |
| SCHEMBL13569788 | 0.77 | KCNH2 (0.60) | CACNA1IKCNH2CACNA1GCACNA1HMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | PRAXIS PREC MEDICINES INC (US) | 2020-05-20 | — | — | EP | disclosed |
| EP-2300007-B1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | TARO PHARMACEUTICALS INC (CA) | 2018-04-18 | — | — | EP | disclosed |