Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16385162 | 0.91 | RAB9A (0.59) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL16385156 | 0.89 | KDM4E (0.51) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL16385399 | 0.86 | KDM4E (0.49) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL17144996 | 0.85 | KDM4E (0.65) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL16385157 | 0.85 | MAPT (0.48) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL8775655 | 0.81 | NPC1 (0.50) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL10207982 | 0.81 | NPC1 (0.54) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL3995066 | 0.80 | ALDH1A1 (0.60) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL16385406 | 0.80 | KDM4E (0.52) | MAPTKDM4ERAB9ANPC1MEN1 | |
| SCHEMBL12326161 | 0.80 | PDGFRB (0.58) | MAPTKDM4ERAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970353-B1 | MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS | VERTEX PHARMA (US) | 2018-04-18 | — | — | EP | disclosed |